Early diagnosis of alcohol-related liver disease could prevent death

Death from alcohol-related liver disease could be prevented with early diagnosis and intervention, says new study: Patients dying of alcohol-related liver disease had frequent interactions with secondary care services prior to their death, and a new study has found that these opportunities to address their high-risk drinking behavior could have been missed.

The research found that people who died from alcohol-related liver disease (ARLD) had an average of 25 interactions with hospitals within Nottinghamshire prior to their death.

The study, which is published in the Drug and Alcohol Review, was led by Dr Mohsen Subhani and Rebecca Elleray, from the School of Medicine at the University of Nottingham.

Alcohol-related liver disease (ARLD) is a preventable cause of mortality. In 2020 in the UK, the alcohol-related mortality rate was the highest reported since 2001, with a 19.6% increase compared to 2019*. In 2018 the World Health Organisation reported that alcohol use contributed to over 3 million deaths (men 2.3 million, women 0.7million), and 132.6 million disability-adjusted life years (DALYs) globally per year**.

ARLD is asymptomatic in the early stages and often presents late when the prognosis is poor. Early identification of alcohol misuse is therefore key and as stated there may be numerous opportunities to identify alcohol misuse and/or diagnose ARLD earlier.

There has been limited research describing where and how patients with underlying ARLD interacted with healthcare professionals. There is also little known about specific factors associated with delayed diagnosis. Studies have lacked a detailed linked assessment of health-related contacts prior to death, which limits understanding of opportunities for intervention.

In this new study, experts looked to analyse retrospective data from the Office for National Statistics (ONS) and Hospital Episode Statistics (HES) databases to identify adult residents (aged over 18) of Nottinghamshire who died of ARLD over a 5-year period (between Jan 2012-31 December 2017). Death was used as the primary outcome, and an analysis was carried out to test the association between key variables and mortality due to ARLD.

Over 5 years, 799 ARLD deaths were identified. More than half had no diagnosis or a diagnosis of ARLD less than 6 months before death.

Emergency presentation at first ARLD diagnosis and white ethnicity were significantly associated with a delay in diagnosis. Overall, the cohort had a median of 5 hospital admissions, 4 accident and emergency attendances and 16 outpatient appointments in the 5 years before death. Treatment was provided by a range of specialities, with general medicine the most common. Alcohol was associated with most admissions.

Dr Mohsen Subhani, the corresponding author of the study, said: “Our study shows that people with ARLD had an average of 25 interactions with hospitals within Nottinghamshire prior to their death.

“These interactions were mainly in outpatients, and over 50% of patients were only diagnosed with liver disease in the last six months before death.

“This data clearly highlights the deficiencies in ARLD secondary care and stresses the importance of the Health and Education England and NICE message that “every contact matter” and ” alcohol screening and advice is the responsibility of every healthcare professional”. We now have a powerful methodology that can be used to evaluate and improve how alcohol issues are managed and where action can be best targeted.”


*Office for National Statistics (ONS). Quarterly alcohol-specific deaths in England and Wales: 2001 to 2019 registrations and Quarter 1 (Jan to Mar) to Quarter 3 (July to Sept) 2020 provisional registrations. In: statistics OfN, editor. 2021. Access online: https://www.ons.gov.uk/. Date accessed 01.01.2021. 2.

**World Health Organisation (WHO) (2018). Global status report on alcohol and health. Access online: https://apps.who.int/iris/handle/10665/274603. License: CC BY-NC-SA 3.0 IGO. 2018.

The DOI for this paper is 10.1111/dar.13482

The University of Nottingham is a research-intensive university with a proud heritage. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia – part of a globally connected network of education, research and industrial engagement. Ranked 103rd out of more than 1,000 institutions globally and 18th in the UK by the QS World University Rankings 2022, the University’s state-of-the-art facilities and inclusive and disability sport provision is reflected in its crowning as The Times and Sunday Times Good University Guide Sports University of the Year twice in three years, most recently in 2021. We are ranked seventh for research power in the UK according to REF 2021. We have six beacons of research excellence helping to transform lives and change the world; we are also a major employer and industry partner – locally and globally. Alongside Nottingham Trent University, we lead the Universities for Nottingham initiative, a pioneering collaboration which brings together the combined strength and civic missions of Nottingham’s two world-class universities and is working with local communities and partners to aid recovery and renewal following the COVID-19 pandemic.

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