Aluminium and autism

Does human exposure to aluminium  have a role to play in autism spectrum disorder (ASD)? Research at Keele University published in the Journal of Trace Elements in Medicine and Biology provides the strongest indication yet that aluminium is an aetiological agent in ASD. The aluminium content of brain tissues from 5 donors who died with a diagnosis of ASD was found to be extraordinarily high, some of the highest values yet measured in human brain tissue. Why for example, would the occipital lobe of a 15 year old boy with autism be 8.74 (11.59) micrograms/g dry wt., a value which is at least 10 times higher than might be considered as acceptable for an aged adult never mind a child?

However, while the aluminium content of each of the 5 brains was shockingly high it was the location of the aluminium in the brain tissue which served as the standout observation. The majority of aluminium was identified inside non-neuronal cells including microglia and astrocytes.

However, while the aluminium content of each of the 5 brains was shockingly high it was the location of the aluminium in the brain tissue which served as the standout observation. The majority of aluminium was identified inside non-neuronal cells including microglia and astrocytes.

Aluminium was also found in lymphocytes in the meninges and in similar inflammatory cells in the vasculature. There was clear evidence of inflammatory cells heavily loaded with aluminium entering the brain via the meningeal membranes and the blood-brain-barrier.

The fact that the majority of aluminium found in brain tissues in ASD was intracellular and associated with non-neuronal cells is, at least for now, unique to ASD and may begin to explain why young adolescents had so much aluminium in their brains.

The fact that the majority of aluminium found in brain tissues in ASD was intracellular and associated with non-neuronal cells is, at least for now, unique to ASD and may begin to explain why young adolescents had so much aluminium in their brains.

Perhaps there is something within the genetic make-up of specific individuals which predisposes them to accumulate and retain aluminium in their brain, as is similarly suggested for individuals with familial Alzheimer’s disease. The new evidence strongly suggests that aluminium is entering the brain in ASD via pro-inflammatory cells which have become loaded up with aluminium in the blood and/or lymph, much as has been demonstrated for monocytes at injection sites for vaccines including aluminium adjuvants. Perhaps we now have the putative link between vaccination and ASD, the link being the inclusion of an aluminium adjuvant in the vaccine.

Professor Chris Exley

Professor Chris Exley

Professor in Bioinorganic Chemistry Keele University
Honorary Professor, UHI Millennium Institute
Group Leader - Bioinorganic Chemistry Laboratory at Keele
Professor Chris Exley

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DBond
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DBond

Thank you for this report.

Ketsa
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Ketsa

Thank you for your research and findings! Can we ever say that a vaccine containing Aluminium as an adjuvant is safe? Why hasn’t more research been done before the mandating of vaccines in various countries and states worldwide? Is this not a medical scandal?

Heptaglemious
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Heptaglemious

Any reason why you didn’t include any healthy controls? Or baseline your aluminium specific marker anmd prove it is actually aluminium specific? Or re-run larger numbers of samples when you had such large standard deviation? I’d also be interested to hear why why you claimed vaccines as a cause without showing any evidence of vaccine status of the donors, since the very large standard deviation looks a lot like contamination or experimental error.

Chris Exley
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Chris Exley

Whither (Peer) Review of Science? Most scientists accept that while peer review is by no means a guarantee of scientific credibility it is nevertheless the best imperfect solution to policing the scientific literature. There will be occasions where what could be considered as equivocal science survives peer review and there are processes in place to address such anomalies including a Letter to the Editor of the ‘offending’ journal. In this way, mistakes can be rectified and differences in opinion discussed under an umbrella of scientific scrutiny. In these days of burgeoning social media and including open access publication of scientific… Read more »